Nature vitamin H is widely exist in the kidney, liver, pancreas and other organs of the animals as well as egg yolk, yeast, milk. In recent years, the international market demand for Vitamin H is continuously strong growth, which push the production. The increase in the production and export of vitamin E, which shows bright maket prospects.
Vitamin H is mainly used in medicine and health, nutrition fortifiers, feed additives, cosmetics material and health products, as well as drinks and so on. Vitamin H has a wide range of physiological effects, it is an important coenzyme of body fat metabolism and other carboxyl reaction, a certain role in fat metabolism and nucleic acid and protein synthesis. Lack of vitamin H may cause hair loss, dermatitis, and weight loss. Mainly used in clinical vitamin H deficiency and the prevention of skin diseases.
Vitamin H is an important nutrient supplement, the United Kingdom Vitamin H reference nutrient intake per person per day 10¼g-20¼g. U.S. adult recommended intake per person per day 30¼g-100¼g. China Fortified Food hygiene standards under the Vitamin H is used in foods for infants and young children when 0.1mg-0.4mg/kg drink liquid of 0.02 mg of -0.08 mg / kg.
Vitamin H is also an important feed additive, it is essential for livestock growth and development of a biological catalyst, livestock and poultry during growth and development of a number of factors, such as weight gain, feed conversion, meat production, meat quality, fur, egg and so influential. General per kilogram of feed required to add 0.15¼g vitamin H. Vitamin H is usually used as feed additives, processing into the preparation of 2%.
Vitamin H, more complex structure, the production of technical difficulty. The production method of extraction, fermentation and chemical synthesis. Due to the natural vitamin H is a wide range of egg yolk, milk and animal liver, kidney, pancreas and other organs, it can be extracted from these substances, vitamin H, alumina chromatography extraction by distillation under vacuum refining derived. However, the production of small, high cost, the products are mainly used in the production of biological reagents, for teaching and research. Available microbial fermentation, the fermentation of this method is not easy, the yield is not high, the quality is not stable enough. Over the years, biotin manufacturers have been studying the chemical synthesis method for the production of vitamin H, until the early 1980s, this problem was able to break. Chemical synthesis method is based on 2 – Amino-3– SH sodium propionate as the starting material, condensation of chloro-acetic acid, and then after acylation, esterification, hydrolysis, decarboxylation, condensation, oximation, hydrogenation, hydrolysis, cyclization, etc. many reactions in the system.
For the process of Vitamin H production is complex, needs long time, and the technique is difficult, now only several enterprises master the production process, and can industrial production, also the annual production is very rare in the world. At the end of 20 century, the world annual production is about 45 tons, and now has reached about 60 tons.