Awakening Stem Cells with Vitamins/Cell, May 4, 2017 (Vol. 169, Issue 5)

Awakening Stem Cells with Vitamins/Cell, May 4, 2017 (Vol. 169, Issue 5)

Billions of blood cells die every day and need to be replaced by new ones. In this video, Andreas Trumpp shows that Vitamin A is a key signal that controls both the transition of hematopoietic stem cells from a “sleep-mode” state called dormancy to an active state and how Vitamin A metabolites may help to improve treatment of blood disorders and leukemias.

Check out the paper at: https://www.cell.com/cell/fulltext/S0092-8674(17)30464-6.

Nina Cabezas-Wallscheid, Florian Buettner, Pia Sommerkamp, Daniel Klimmeck, Luisa Ladel, Frederic B. Thalheimer, Daniel Pastor-Flores, Leticia P. Roma, Simon Renders, Petra Zeisberger, Adriana Przybylla, Katharina Schönberger, Roberta Scognamiglio, Sandro Altamura, Carolina M. Florian, Malak Fawaz, Dominik Vonficht, Melania Tesio, Paul Collier, Dinko Pavlinic, Hartmut Geiger, Timm Schroeder, Vladimir Benes, Tobias P. Dick, Michael A. Rieger, Oliver Stegle, and Andreas Trumpp (2017). Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell.

And read more great research at Cell: http://www.cell.com/cell/home.

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