The initial study of tretinoin is more concentrated in the tumor effects, especially for acute promyelocytic leukemia. Now it has been successfully used in clinical trials. In recent years, the kidney, liver, lung, and other appropriate animal model experiments have confirmed retinoic acids role in anti-fibrosis and cell proliferation. The cosmetic raw material suppliers also make the tretinoin applied in treating dermatosis of fibroblasts proliferation and excessive collagen deposition.
Tubulointerstitial fibrosis is the common pathway for a variety of chronic kidney disease to end stage renal failure. The degree of tubulointerstitial damage and glomerular filtration rate was negatively correlated with prognosis than the glomerular lesions. Classic unilateral ureteral obstruction model, given retinoic acid intervention, and 7 days after the detection of relevant indicators, the results show that retinoic acid can significantly reduce the degree of interstitial fibrosis, reducing the infiltration of mononuclear macrophages, lowered the TGF- ²1 and procollagen I mRNA expression, thus contributing to the prevention and treatment of fibrosis. Many Chinese scholars have research in all angles. The results show that it has a protective effect on tubulointerstitial fibrosis.
The occurrence of liver fibrosis is caused by the synthesis and degradation of extracellular matrix components imbalance in the liver. Modern studies have shown that the Ito located in the sinusoidal function of storage and metabolic VitA, collagen production in liver fibrosis cells. RA can reduce the CCl4-induced hepatic fibrosis in rats `, type b collagen and other extracellular matrix accumulation in the liver, inhibition of changes in fat-storing cells to myofibroblasts. In vitro experimental studies have shown that retinoic acid can inhibit Ito 3H-TdR incorporation and reduce the primary cultured fat-storing the DNA, RNA content. A recent study showed that small doses of all-trans retinoic acid by reducing the expression of chronic alcoholic liver injury in rat liver fibrogenesis factor of TGF-²1 and CTGF and Colla1 inhibit the formation of early alcoholic liver fibrosis. Seen in this light, the RA is expected to become a new drug for the treatment of liver fibrosis.
Pulmonary fibrosis is a common outcome of a variety of different causes of interstitial lung disease. In pulmonary fibrosis, the retinoic acid lowered lung fibroblast collagen expression, inhibition of fibrosis, the development. In addition, the model of lung injury in rats exposed to hyperoxia, retinoic acid can adjust a variety of fibrosing factors, such as TGF-beta1, VEGF, IL. Compared with the control group, the lesion is reduced significantly. Retinoic acid reduces the radiation-induced lung injury and provides a theoretical basis for clinical anti-fibrosis drug development by acting on the IL-6/IL-6R system.
The final pathological changes of hypertensive damage to the cardiovascular system due to cardiac myocyte hypertrophy and collagen induced myocardial hypertrophy and diastolic dysfunction, vascular smooth muscle cell proliferation caused the atherosclerosis. AtRA increased ACE2 gene expression, thereby reducing blood pressure, and to some extent, to reduce myocardial damage. Percutaneous transluminal coronary angioplasty is safe and effective methods of treatment of coronary artery disease, restenosis after also become a big problem in the cardiovascular sector. AtRA treatment group can significantly reduce damage to the neointimal area and increased lumen area. It suggests that atRA plays a role in suppression of the damaged intimal hyperplasia. If people would like to buy tretinoin, they can consult with doctors and pharmacies.
The studies from cosmetic raw material suppliers confirm that tretinoin also has a certain role on a number of fibrotic diseases, such as scar repair of traumatic skin, proliferative vitreo retinopathy and so on. Retinoic acid has some preventive effect on various types of fiber proliferative diseases. It shows a good prospect. However, these effects are mostly based on animal studies. Clinical application of the drug needs further discussion and observation about mechanism and efficacy.